The B5 New Acne Cure - Pantethine
87Try The New Acne Cure - Experimented For Years
What if you get rid of your acne 2 days from now? No topical applications, no unknown remedies, no toxic drugs, and no overdose supplements. You will just fine tune the supplements you may be already taking.
After the tremendous response to my hub about facial masks, I decided to give you more of my experience as a pharmacist. Today I will present to you the best successful, experimented cure of acne that I have been recommending people for years. It is based on the brilliant basics of biochemistry and supported by recent scientific findings.
The recommended regimen here is aimed at relieving symptoms of acne, it is to be used temporarily and for a short time. Long term use of high doses of these supplements may induce side effects, and some of them may be serious. If you plan to use them for a long period consult your doctor.
12 Years Boys Have No Acne
Children are free from acne until puberty, when all the body activities
are directed towards building more bones and muscles, and preparing the body to reproduce (to preserve life).The pituitary gland (maestro gland) hormones direct the body to serve these purposes, thus :
• Growth hormone increases utilization of fats for energy production, increases lipolysis (fat breakdown by fat cells), spares carbohydrate, and increases protein synthesis.
• Thyroid Stimulating Hormone(TSH) stimulates the thyroid gland to secrete Thyroid hormones, and these increase oxygen utilization and metabolic rate, as well as they increase glucose absorption.
• Follicle Stimulating Hormone (FSH) and Lutenizing Hormone (LH) causes
increased bio-synthesis of sex steroids by the ovaries and testis. Sex hormones build muscles and raises blood glucose so as to be maintained within a certain range.
The net result is increased energy production from fats, decreased energy production from carbohydrates (as it is needed for protein metabolism) , increased protein synthesis, and increased bio-synthesis of sex hormones. The biochemical translation of that is, the production of huge amounts of COENZYME A.
Acne Cure Supplements
Coenzyme A and Acne
Coenzyme A is the central molecule in our metabolism, it combines acetate that comes from carbohydrates, protein, and fat metabolism to form Acetyl-Coenzyme A, the only molecule that the mitochondria use to produce energy through Krebs cycle. Also fat synthesis - including steroidal hormones - starts with Acetyl Coenzyme A. Acetyl choline the neurotransmitter of all para-sympathetic nervous system can not be synthesized without acetyl-coenzyme A.
Coenzyme A is formed by stepwise union of Cysteine (amino acid), ATP
(high energy molecule), and Pantothenate (Vitamin B5). ATP is provided by metabolism, Cysteine if not present in food can be derived from Methionine (amino acid), and Vitamin B5 can be only provided by food.
The body deals with the high demand of an essential nutrient in such a way to maintain the functionally more important reactions, while at the same time slowing down the less important ones (or why a certain disease is debilitating?).
In our case, where Coenzyme A is a pivotal molecule in at least 70 metabolic pathways, the body chooses to utilize Coenzyme A and excess fats to build sex hormones, leaving excess fats unprocessed and stored. Were there extra amounts of Coenzyme A, the body would metabolize the excess fat in the sebaceous glands.
Now we can easily understand that acne is due to un-metabolized fat that is accumulated in the sebaceous glands, due to insufficient amounts of Coenzyme A,i.e., acne is due to slow metabolism of excess fat.
Why It Is Hormones Biosynthesis and Not Androgen Effect
The reason acne first erupts at puberty is not effects of hormones, but rather metabolic, it is secondary to deployement of a substantial amount of coenzyme A to the purpose of synthesis of sex hormones. In the following examples we may see that, it is not the androgen that is the cause of acne:
• Eunuchs (early castrated males) rarely exhibit acne, while normal adult males may exhibit adult acne
• Two groups of adolescent boys with the normal blood levels of androgens may exihibit differnt incidence of acne
• Stress related acne ( prior to examination, tension, insomnia...etc)
is caused by increased synthesis of corticosteroids that the body secretes to combat stress. The same thing apply for adult acne of people who have not had acne as teenagers
• The premenstrual flare of acne patients due to increased levels of progesterone which is not an androgen
• Rapid decline in incidence of acne after puberty is due to cessation of need of increased sex hormones synthesis
• Biotin and Nicotinamide are important vitamins of lipid metabolism, and with vitamin B5 they may help cure acne, yet when they are used alone, they are far less effective in treating acne
• Frequently seen acne with those secreting tumors of the ovary, testis and adrenals, in people with variant ages
Excess Fat
Acne Cure With Coenzyme A
The precursors of coenzyme A are ATP which is very abundant in the body of adolescent people, Cysteine which is non essential amino acid that can be supplied with food or derived from the essential amino acid Methionine, and Vitamin B5 (Pantothenic acid) which is essentially supplied by food.
Pantothenic acid (vitamin B5) supply to increase body production of coenzyme A , has been recommended by Dr Lit-Hung Leung in high doses reaching 1000-1500 times its recommended daily intake which is 10 milligrams per day. The recommended dose is so high (10-15 grams/day), because vitamin B5 is a water soluble vitamin, i.e., with each heart beat the unused B5 molecules pass into the kidney to be excreted. It follows that Vitamin B5 should be present all the time to capture any free Cysteine.
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Add Cysteine to Reduce Pantothenic Dose
Since the demand for coenzyme A increases in adolescence, the need for Cysteine must increase. Cysteine is a sulfur amino acid that is heavily used in building keratin, which is an important constituent of the skin (which increases largely in size during adolescence), growing wanted and unwanted hair, and also used in forming nails.
Cysteine free pool in the liver has a narrow range, since the liver cells tightly regulates it to keep it within that range. The liver synthesises Glutathione as a reservoir of cysteine. Glutathione is the primary tool of the liver for detixification. It has a vital role in many cell cycle related events that are needed during tissue repair. It is also vital for maintaining functioning of the immune system.
Cysteine with Glutamic acid (another amino acid) are considered by some researchers to be essential elements for adolescents.
Administration of Cysteine is the only means by which we can reduce the dose of Pantothenic acid. I have recommended the combination of Pantothenic acid + Cysteine for many acne patients for more than 10 years with great results in curing acne.
Taking 0.5-1 grams of Cysteine per day reduces your intake of Pantothenic acid to only 1-1.5 grams per day (they will be combined).
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Pantethine, The New Relief
The metabolic pathway of synthesis of coenzyme A involves a compound called Pantetheine which is the direct precursor of coenzyme A. It is now produced in the stable form pantethine, as it involves 2 molecules in the disulfide form of pantethine. It has an extra advantage of being sustained over time, since every molecule has to be split first, and this delays its elimination.
It was intensively researched for its cholesterol and lipid lowering properties (aren't they excess fats?), and has become very popular for cardiovascular support. The literature about Pantethine is full of details about that property, and this made me reluctant to recommend its use for acne, until I found some people are already using Pantethine to cure acne as you can read in the link below.
The dose of Pantethine in most human studies is 900 mg per day and this may be a good guide for us to start with 300 mg three times daily until improvement, it is supposed to improve acne within 2 days.
Read About People Using Pantethine for Acne
- Acne.org Message Boards - Pantothenic vs. Pantethine?
Forum discussion between people using Pantothenic acid and others using Pantethine. Use Message boards link and type in "Pantothenic vs.Panthine"
It is Time To Start
In the below link, there is the details of each product you may choose to cure acne. I included both systems of treatments to overcome the problem of individual variations, so that you may choose the most convenient one that meets your requirements.
If you like take some adjuvants, you may take supplements that contain
Chromium, Zinc, Vitamin E, Vitamin B complex, and Vitamin A, but it is not a must.
Acne Cure Supplements
- Acne Supplements
Go through the details of each item and do not forget that pantothenic acid is combined with Cysteine (1 capsule of each 2-3 times daily). Only Pantethine is taken alone (1 capsule 3 times daily).
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Comments or QuestionsLoading...
Hi Mat,
If you dealt with acne for sometime, you should have heard about use of Pantothenic acid for treating acne, this new treatment is just a modification of the treatment, Pantothenic acid is administered for formation of Pantotheine which is the precursor of Coenzyme A, it is a reduction of one step that costs the body some side effects and some more money, if you find some day Coenzyme A in tablet form take it, this is the final step in the biochemical pathway!
Read about use of Pantethine in message boards of acne.org website, the link is given above.
Yes it is safe, it is recommended to be more safe than pantothenic acid in the currently used doses.
Want to exchange links between our two acne hubs?
First, great blog, i know the b5 works i used it a lot. Now i am very curious if i can do it without the 10 grams i took.
After reading all this, this is my plan.
3 times a day Panthetine 300mg, carnitine 200 mg, b5 500 mg and cysteine 500 mg
So i take all paths.
My question is: When shall i take this with or without meal?
The reason i ask this is that i know that amino acid will compete with each other. But the b5 only worked with me when i took it with a meal. But i want the b5 to catch the cysteine off course.
Excuse my English it is not my language..
Thanks for the great peace of writing in this blog!
First, great blog, i know the b5 works i used it a lot. Now i am very curious if i can do it without the 10 grams i took.
After reading all this, this is my plan.
3 times a day Panthetine 300mg, carnitine 200 mg, b5 500 mg and cysteine 500 mg
So i take all paths.
My question is: When shall i take this with or without meal?
The reason i ask this is that i know that amino acid will compete with each other. But the b5 only worked with me when i took it with a meal. But i want the b5 to catch the cysteine off course.
Excuse my English it is not my language..
Thanks for the great peace of writing in this blog!
Hi Mark,
Thanks for reading the whole article and you are welcome any time.
The best thing is to take the supplements with meals to avoid any undesired effects on an empty stomach, and don't worry about the competition between amino acids, they are already available in foods we eat.
Good luck!
Instead of using alot of money in trying to cure acne, i would prefer that one tries all the natural methods, that are expense free in avoiding acne. Here are some of the methods that can help you keep off these.
Cloth; You should avoid garments made exclusively of Lycra and nylon if you are prone to body acne since some synthetic fabrics can strap the heat and moisture against your skin. This creates a fertile breeding ground for the bacteria that contribute to acne
For moderate exercise, use light weight, loose fitting cotton or a lycra-cotton blend. Natural fabrics allow the skin to breath and loose garments are less likely to cause friction. If you exercise vigorously and work up a good sweat, try some of the new fabrics designed to wink moisture away from your skin.
Say no to alcohol; if you use a toner avoid products with high concentration of isopropyl alcohol, or common alcohol. A strong astringent alcohol strips the top layer of your skin causing your sebaceous glands to produce more oils resulting to dry red skin and possibly more blemishes.
Hello
Could u please tell me what would be the most important supplements to take for acne, out of those which you have mentioned.
Many Thanks
John Hooks
Hello
Could u please tell me what would be the most important supplements to take for acne, out of those which you have mentioned.
Many Thanks
James
I've been taking Jarrow Formulas Pantethine 450mg two times a day for three weeks now. Haven't noticed any significant change to my acne. No cure within two days. Going to finish the bottle since i paid 23 dollars for it.I'm 5'5.5 and 146 pounds. Do you think i should be taking over 1,000mg a day and how much should you suggest is the amount needed to metabolize more fats in order to get a substantial difference in my acne. Is taking 1800mg a day too much?!
Hi CALI 01,
Thanks for visiting!
I think if you take one more capsule of a supplement is not too hazardous, try combining with your best treatment you've noticed an improvement with it before.
I wish you the best of luck.
For a majority of people Pantethine works better than PA. Pantethine is the biologically active form of PA and has been seen to offer more benefits than PA.
Good info!
Hi do you have to take anything with pantethine for it to work like cysteine or b complex? And can a small dose be jus as effective to someone who gets regular few spots not full on acne? Overall is it more effective then PA as it seems easier as its less pills
Hi Dan,
Thanks for visiting!
Cysteine is needed to form pantethine, so there is no need to take it however if you like to take some B complex, it is OK.
What do you thinks better to take as ive bought both incase one dont work i can try the other pantothine sounds easier but dont no how effective they both are compared to each other
Start with Pantethine and see.
Do they have to be taken after/ with food or does this not make a difference?
After meals.
Firstly great article thanks for compiling it.
I have been reading about the internet and there seems to be quite a few cases where people achieve better results using pantothenic acid in 10g doses as appose to taking approximatley 750mg of pantethine three times a day.
I have moderate acne and have never tried this type of treatment before, i want to give this treatment a go; so which should I start with pantethine or pantothenic acid???
Hi Tom,
Thanks for visiting !
The purpose of use of Pantothenic acid is to synthesize Pantethine, isn't it much easier to use pantethine? by using it you can reduce the huge dose of pantothenic which has some impacts on the tissues.
Hello Mr elqalatawy,
Thank you for this information!
I would like to ask you a question regarding methionine: You said that cysteine is derived from methionine, so if one would like to take methionine instead of cysteine, what quantity of methionine will be required in order to produce the recommended 1-1.5 grams of cysteine daily?
Thank you in advance!
Hi Mihai,
Thanks for the visit.
As you see the whole idea is to increase the existence of a certain nutrient, no calculated values, so you may take Methionine in its recommended dose as a supplement, I think 1 g daily is sufficient.
L-cysteine or N-Acetyl-Cysteine? Thank you
Hi Mike,
Thanks for stopping by.
it is L-Cysteine.
Why is not better N-Acetyl-Cysteine than L-Cysteine? N-Acetyl-Cysteine (NAC) has all the properties of L-Cysteine but is more water soluble and said to be more bio-available than L-Cysteine.
The enzyme that is involved in the reaction catalyzes the reaction between Pantothenate and L-cysteine, it can not act on N-Acetyl-Cysteine because it has specific sites for the reactants, like the lock having a specific key.
diga adeus ao acne
I have read on various websites that Coenzyme A is synthesized within the body by three precursor chemicals (pantothenic acid, cysteine, and ATP -Adenosine-5'-triphosphate). Even if we take pantethine instead of pantothenic acid, why would we not also want to supplement with cysteine?
Hi John,
Thanks for the comment.
Pantothenic acid reacts with cysteine to produce pantethine
which further form coenzyme A, thus when we use pantethine we reduce the reactions by one step.
Marvellous job for the valuable information.
Hi elqalatawy,
I used your advice and I'm taking 500mg L-Methionine and 500mg B5 two times a day. It does reduce sebum and acne, although I don't have a lot of acne anymore (I had it bad when I was younger). I just wanted to report that it works and to thank you again for your site!
Pantothenic acid and hairloss.
If you search the net, there are a lot of people complaining of hairloss when taking large doses of pantothenic acid. There are quite a few theories:
1) Pantothenic acid lowers Biotin causing hairloss
2) Pantothenic acid lowers cysteine causing hairloss
3) Pantothenic acid raises DHT levels causing hairloss
4) Pantothenic acid decreases pore size causing hairloss
There are enough people reporting it, that it has me concerned. Please comment on the following:
1) Why does Pantothenic acid especially in large doses cause hairloss?
2) What can be done to prevent pantothenic acid from causing hairloss?
Thank you!
will there be any rebound reaction after stopping pantethine? thanks
hello, may i know will there be or any reported case of rebound effect after stoppig pantethine?
Hi Ken,
There are no rebound effect after stopping pantethine per se, yet you should be acquainted to the fact that whenever there is a factor that slows down fat metabolism and causes accumulation of sebum, you will experience acne and you will need to take pantethine again.
Good luck.
is it more effective to take pantethine or is it more effective to take pantothenic acid and cysteine?
Hi Harry,
I have tried cysteine and pantothenic acid, it is supposed that the body will utilize them to form pantethine. Theoretically, pantethine is better yet I did not try it.
with pantethine, can you take 2 300mg pills in the morning and one at night or does it have to be spread out throughout the day?
Hi jon,
It is a supplement that can be taken any way and you have to try.
what do you think about combining pantothenic acid with pantethine? I have read several places that it is most effective this way!
Hi sam,
Just try them.
I tried pantethine for 1.5-2 months. I can't say that it made that much of a difference in my skin or in my oil production. Should I increase the pantethine? How much can I safely take?
Thank you!
Hi Earl,
Keep on the dose but you may add L-Methionine 1 gram/day.
Thank you for the response back. I am currently taking 900 mg of the pantethine in three divided doses. I am willing to give the Methionine a try. However, I thought that if you are taking patethine you do not need Cysteine or Methionine. Please explain.
Thank you!
Theoretically you do not need these amino acids with Pantethine, however practically there would be a biochemical distraction away from that pathway, so we need to support this same pathway. It is the same idea that made Pantothenic to be advised in 1000 times its recommended daily intake.
In addition to taking the Methionine. I was thinking about adding L-Carnitine. Supposedly it helps transport fatty acids across the mitochondrial membrane where they can be oxidized. In theory it reduces the amount of b-5 you have to take. For more information see - http://jeffreydach.com/2008/09/04/pantethenic-acid
What do you think?
Hi Earl,
Yes it is right, we just try not to reduce expenses. Methionine will reduce the dose of VITAMIN B5.
Thanks again for the response. OK I am trying the Methionine (1,000mg) + Pantethine (900mg). To get the maximum oil/sebum reduction, do you think I should add some L-Carnitine? If so, how much?
Thanks for all your help!
Hi Earl,
You are welcome any time.
There is no need for L-Carnitine, but if you would like to explore take it in its recommended dose.
From what I understand Pantethine turns into Coenzyme A. Coenzyme A is responsible for oxidizing or burning up fatty acids which in turn reduce oil or sebum on the skin. L-Carnitine is a transporter of fatty acids. It transports fatty acids to be burned up as energy. As an analogy. Coenzyme A is the furnace that burns up fatty acids. Carnitine is the delivery truck that brings fatty acids to the furnace.
Doesn't it make sense to take both of them?
Thanks!
Earl,
You are right except that Coenzyme A is the tray that introduces the splits of fatty acids into the furnace one by one.
The question is why do we make all these efforts to erase fatty bumps? they will show again frequently!
My point is that we keep acne at bay with the least efforts and costs, whenever it comes.
If you want to try it go ahead and try, it's your money.
Your article says to take the pills (Pantothenic acid and Cysteine)temporarily and for a short time. How long would you recommend taking them for then. I was thinking 2 weeks on one week off.
Thanks
You use them until acne is gone. If you don't get good result you may shift to using Pantethine http://elqalatawy.hubpages.com/hub/Acne-Cure-Guara
Mat 2 years ago
Does this really work? why we did not hear about it before? is it safe?